Weight loss supplements are become incredibly popular within the health and fitness industry.
And with promise to promote fat loss, without the need to make dietary changes and introduce exercise interventions, you can see why.
Of these weight loss supplements, thermogenic continue to be the most popular, promising to aid weight loss by increase the ability of the body to use fat for energy while simultaneously increasing our metabolism.
These supplements are often associated with some nasty side effects due to the inclusion of both stimulants and diuretics into their ingredient list.
One of the more recent thermogenic supplements to hit the market is Synedrex.
Synedrex is a fat burning thermogenic supplement made by metabolic nutrition.
It comes in capsule form and includes a number of ingredients that are suggested to promote fat loss through a large number of different mechanisms.
Synedrex is advertised as the most powerful fat burning supplement on the market today, and differs from other thermogenic supplement in its recommendations in that it suggests you take no more than two capsules a day, with one capsule being the optimal amount recommended.
Synedrex claims to increase metabolism and decrease body fat, while also reducing appetite, WITHOUT any of the nasty side effects associated with other thermogenic compounds.
But does synedrex meet these lofty claims?
There are a number of different ingredients, both natural and pharmaceutical, appearing within Synedrex that are suggested to play a role in increasing metabolism and promoting fat loss.
But how do they interact with the body?
While Methylxanthine sounds fancy, it is actually just a form of caffeine, an ingredient which is found regularly in stimulant based thermogenic supplements.
It is well known that caffeine is found naturally in both tea, coffee and the cacao plant. It is one of the most commonly consumed (legal) drugs in the modern world, where it is well renowned for its stimulating effects on the human body. Caffeine works by stimulating the brain and central nervous system at a cellular level, causing reduced feelings of fatigue, and increasing feelings alertness.
In conjunction with its influence on energy levels, caffeine consumption has also been associated with increases in weight loss.
Once consumed, caffeine is rapidly absorbed into the blood where it transported to the liver. Once in the liver, is it is broken down and shuttled around the body, until it reaches the brain.
Once caffeine has reached the brain, it proceeds to stimulate the central nervous system, where it creates feelings of alertness, while reducing sensations of fatigue.
It is by this same interaction that caffeine also stimulates fat loss.
The consumption of caffeine has been shown to increase the resting metabolism of humans by up to 11%, while increasing fat metabolism specifically by up to 13% . By both increasing our ability to use fat for energy, while also increasing the amount of energy we burn at rest, caffeine can improve our ability to burn fat significantly.
It is important to note that high doses of caffeine often have side effects such as jitteriness, nausea, and in more ever cases, migraines.
Methylpenate Citrate is a substrate that is more commonly known as 1,3-dimethylbutylamine (DMBA).
DMBA is a compound that has recently grown in popularity at quite a rapid rate. The reason for this is that it has an extremely similar make up to a stimulant known as DMAA. DMAA was used extensively as a stimulant based fat burner until it was banned by the FDA due to the number of dangerous negative side effects it was shown to induce.
DMBA not only shares a similar chemical make up to DMAA, but also acts in a very similar way.
DMBA is used extensively as a fat burning supplement where it has been shown to increase feelings of energy (which is further exacerbated when used in conjunction with caffeine), while causing a considerable increase in metabolic rate.
While this increase metabolic rate associated with DMAA supplementation has been said to promote considerable fat loss, it also comes at a cost.
DMAA has been linked to anxiety, agitation, a tendency to crash physical and mentally after consumption, headaches, and even cardiovascular issues (associated with prolonged periods of causing high resting heart rate.
Furthermore, due to how recently DMAA has actually hit the market, there is little known on the long term side effects associated with supplementation due to a lack of current research.
Sulbutiamine is a manmade compound that has a chemical makeup extremely similar to that of the b-vitamin thiamine.
Sulbutiamine supplementation has shown to increase thiamine levels in the brain, where it has been suggested to improve feelings of lethargy and fatigue.
While this sounds a suitable inclusion in a fat burning supplement, there is actually no scientific evidence to suggest this is truly the case.
Sandalwood has been used extensively in traditional eastern medicine as a relaxant, and has gained some popularity as a supplement suggested to reduce emotion related food cravings.
While it has been said that sandalwood supplementation can act as a relaxant, reducing stress related food cravings, and subsequently increase weight loss, there is no evidence to suggest this is the case.
Yohimbe extract comes straight from the Yohimbe tree, which is a native to Africa.
Traditionally the bark from the Yohimbe tree was used to to help improve erectile dysfunction. In more recent times it has gained popularity as a weight loss supplement.
Yohimbe extract supplementation has gained traction in the wordl of weight loss supplementation due its ability to improve our capacity to use fat as a fuel source via a rapid increase in fat mobilisation. This has been demonstrated through an increase in fat loss as a result of daily Yohimbe supplementation .
As a bonus, Yohimbe has been shown to act synergistically to caffeine, somewhat boosting its fat burning effects.
Alpha Lipoic Acid is a fatty acid that is found in the mitochondria of cells.
Alpha Lipoic Acid is obtained in our diet through the consumption of most meats, and some fruits and vegetables. It plays an integral role in energy metabolism, and has also shown to act as antioxidant within the body where it has demonstrated anti-inflammatory effects.
As such Alpha Lipoic Acid supplementation has shown promise as a treatment for diabetes related symptoms, as well as heart and liver disease. Subsequently, an increased consumption of Alpha Lipoic Acid has also shown to produce minor reductions in resting blood glucose .
This role in resting blood glucose has been thought to produce minor reductions in body weight in obese individuals, suggesting potential as a weight loss supplement, although more research is needed.
Poly-Thyronine is a unique substance rarely found in currently available fat burning supplements due to its lack of research.
It has been suggested to interact with the thyroid gland within the human body, causing an increase in the secretion of thyroid hormones, which subsequently stimulates growth hormone secretion .
This increase in growth hormone has been suggested to increase metabolic rate which can lead to a significant increase in weight loss, although there is no human research to suggest this is the case.
So we can see that there are a number of ingredients within Synedrex that are likely going to promote weight loss.
It is extremely important to note that some of these ingredients, while effective, have been shown to have a number of side effects. This is due the way in which they interact with the body, where they act as potent stimulants.
These side effects may include jitteriness, anxiety, nausea, and could even progress into heart palpitations, cardiovascular disorders such as hypertension, and insomnia.
Furthermore, a number of these ingredients have had minimal research undertaken on human populations, and as such there long term effects are unknown.
For me personally, supplements are meant to aid in the weight loss process caused by a healthy diet and exercise.
While Synedrex is likely to promote additional weight loss, it certainly comes at a cost, potentially causing a number of negative health implications, which are (again, in my opinion) not worth the risk.
1. Acheson, Kevin J., et al. “Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals.” The American journal of clinical nutrition 33.5 (1980): 989-997. Viewed at: http://ajcn.nutrition.org/content/33/5/989.abstract
2. Ostojic, Sergej M. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Research in Sports Medicine 14.4 (2006): 289-299. Viewed at: http://www.ncbi.nlm.nih.gov/pubmed/17214405
3. Porasuphatana, Supatra, et al. “Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alphalipoic acid: a randomized double-blinded placebo-controlled study.” Asia Pacific journal of clinical nutrition 21.1 (2012): 12-21. Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/22374556
4. Grover, Gary J., et al. “Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3, 5, 3′-triiodo-L-thyronine.” Endocrinology 145.4 (2004): 1656-1661. Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/14701670
John has been a fitness enthusiast for over 10 years, starting out while struggling with obesity as a teenager. Over the years he has advised numerous clients on how to transform their physiques and their lives. As a writer on Nutrition Inspector he aims to help others achieve real results by staying clear of the common hype and false claims in the supplement industry!
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