Have you ever heard of the prescription weight-loss drug called Phentermine? Well, Phentramine is a non-prescription alternative that offers thermogenic and metabolism boosting ingredients and properties. PGH the manufacturers of Phentramine claim to provide only biologically grown ingredients that are specifically meant to help minimize weight gain and promote weight loss.
The official website of Phentramine offers a significant amount of information about both the prescription diet pill and this natural alternative. As their spellings are so similar, it can make things a bit confusing for customers to tell the two diet pills apart. However, we want to make it clear that Phentermine and Phentramine are not the same things, one is a complete herbal pill and the other one is a synthetic prescription drug.
So can Phentramine live up to its astonishing claims? Or is it just another hyped up diet pill? In this review, we will examine Phentramine thoroughly, summarize the results and give you the final verdict!
How Does Phentramine Work?
Some supplements are focused on appetite suppression, some focus on eliminating fat we already accumulated, and others focus on the prevention of new weight gain.
Phentramine claims to work on all of these things and more. Similar to its synthetic alternative, Phentramine works though the process of thermogenesis, which speeds up your metabolism by increasing the body’s core temperature. Simply put, it helps your body burn fat easier while promoting lean muscle gains.
Additionally, Phentramine aids with those annoying food cravings by acting as a natural appetite suppressant. Therefore you will eat less, and when you eat less you take in a smaller amount of calories, which leads to the burning of all that extra fat accumulated in the body. It also helps in breaking down the fatty tissue and not only that, it stimulates the fat burning potential of your body by decreasing its ability to store fat.
The ingredients are extremely important no matter what kind of supplement you’re buying. Unfortunately, Phentramine provides their ingredients in the form of a proprietary blend. Proprietary blends are never a good thing.
With this trick, manufacturers hide the dosing information for each ingredient putting the consumer at a risk of underdosing and side effects.
Nonetheless, here are the ingredients found in Phentramine:
- Synephrine HCL – This ingredient occurs naturally, but can also be produced synthetically. Synephrine has been reported to boost energy levels and may even result in an adrenal rush for the user. This could help the user lose weight largely because of its ability to break down fats in the body (1). However, these benefits come at a high price. Syneprhine is possibly unsafe and can promote a wide range of side effects, including high blood pressure, headaches, rapid heartbeat, and even stroke. This compound is even banned in the UK and Canada (2).
- Yohimbine HCL – Gained a lot of attention for its effect on weight loss. Yohimbine prevents the production of new fat cells in the body, while reducing the amount of fat cells overall, specifically targeting stubborn fat (3). Besides all the positive effects, Yohimbine has a few negative ones too. Yohimbine is not recommended for children, nursing women, and older individuals. Side effects include high levels of anxiety, escalated heart rate, and the increased risk of heart disease (4).
- Theobromine Anhydrous – Is a caffeine derivative known for its stimulant properties. Theobromine Anhydrous contains flavonoids that promote adiponectin production (Protein hormone), which is responsible for fat breakdown control and glucose levels. It also helps to stimulate the heart, increase urine flow, and widens blood vessels. Theobromine Anhydrous can potentially induce hypertension, cardiovascular issues, and nausea (5).
- Caffeine Anhydrous – Is only a dehydrated form of Caffeine. Caffeine is clinically proven to boost energy levels and reduce fatigue, it also allows you to keep going throughout your physical activity without getting tired (6). Although Caffeine is not recognized as a long-term solution for weight loss since constant use reduces its overall effects. Higher doses of Caffeine can also induce rapid heartbeat, insomnia, stomach pain, and nausea (7).
- Phenylethylamine HCL – This naturally occurring chemical is found in chocolate and helps release dopamine within the consumer’s brain. Dopamine release helps facilitate a better overall mood during your weight loss journey (8).
- 1, 3-Dimethylpehntylamine HCL – Is also known as DMAA, an extract from the Geranium plant (9). This extract is used for its energy boosting abilities and is the main trigger for increasing the metabolic rate. DMAA is currently being investigated for its potential side effects (10).
- Methylsyneprhine HCL – A stimulant drug that’s labeled as an amphetamine with very similar abilities to Synephrine (11). Due to its potentially harmful effects, the FDA has banned this compound. Consequences of taking Methylsynephrine in higher doses or in combination with other stimulant compounds has been linked to nausea, vomiting, agitation, chest pain, increased heart rate, and cardiac arrest (12).
Other ingredients found in Phentramine include: R-Beta-Methyl-Iphenylethylamine HCL, and Mehtylphenylethylamine Tartrate.
The huge problem with the ingredients are the dosages. The manufacturers of Phentramine don’t provide the exact dosage for each ingredient included in the supplement. This makes analyzing any scientific research on any individual ingredient very tough. Or simply put, studies might use different dosages than the ones found in Phentramine.
Therefore, even if scientifically effective, Phentramine ingredients still don’t bring any solid proof. There is also an issue with the compounds that have been FDA banned. These additives are banned for a reason, due to their potential for serious negative effects. These side effects include serious organ damage, heart attack, stroke, and more.
Phentramine does contain some ingredients that could induce mild weight loss benefits, but the quantities they come in are most likely not sufficient. Not to mention the FDA banned additives that can cause overwhelming side effects. Customers have also mentioned how they’ve experienced a range of negative effects.
Phentermine’s official website doesn’t even mention these potential risks, which deceives the customers. Overall, the best option for anyone reading this review is just to choose a different diet pill.
- Ratamess NA, Bush JA, Kang J, Kraemer WJ, Stohs SJ, Nocera VG1, Leise MD, Diamond KB, Faigenbaum AD. “The effects of supplementation with P-Synephrine alone and in combination with caffeine on resistance exercise performance.” J Int Soc Sports Nutr. (2015 Sep 17). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/26388707
- Sidney J. Stohs, Harry G. Preuss, and Mohd Shara. “A Review of the Human Clinical Studies Involving Citrus aurantium (Bitter Orange) Extract and its Primary Protoalkaloid p-Synephrine.” Int J Med Sci. (2012).
Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444973/
- Jay R Hoffman, Jie Kang, Nicholas A Ratamess, Stefanie L Rashti, Christopher P Tranchina, and Avery D Faigenbaum. “Thermogenic effect of an acute ingestion of a weight loss supplement.” J Int Soc Sports Nutr. (2009). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621121/
- Ostojic SM. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Res Sports Med. (2006 Oct-Dec). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/17214405
- Matthew J. Baggott, Emma Childs, Amy B. Hart, Eveline de Bruin, Abraham A. Palmer, Joy E. Wilkinson, and Harriet de Wit. “Psychopharmacology of theobromine in healthy volunteers.” Psychopharmacology (Berl). (2013 Jul). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672386/
- Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A, Feeley M. “Effects of caffeine on human health.” Food Addit Contam. (2003 Jan). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/12519715
- Jennifer L. Temple, Christophe Bernard, Steven E. Lipshultz, Jason D. Czachor, Joslyn A. Westphal, and Miriam A. Mestre. “The Safety of Ingested Caffeine: A Comprehensive Review.” Front Psychiatry. (2017). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445139/
- Meredith Irsfeld, Matthew Spadafore, and Dr. Birgit M. Prüß. “β-phenylethylamine, a small molecule with a large impact.” Webmedcentral. (2013 Sep 30). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904499/
- Brian K Schilling, Kelley G Hammond, Richard J Bloomer, Chaela S Presley, and Charles R Yates. “Physiological and pharmacokinetic effects of oral 1, 3-dimethylamylamine administration in men.” BMC Pharmacol Toxicol. (2013). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852303/
- Bloomer RJ, Harvey IC, Farney TM, Bell ZW, Canale RE. “Effects of 1, 3-dimethylamylamine and caffeine alone or in combination on heart rate and blood pressure in healthy men and women.” Phys Sportsmed. (2011 Sep).
Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/22030947
- Nam Hee Kim, Ngoc Bich Pham, Ronald J. Quinn, Joong Sup Shim, Hee Cho, Sung Min Cho, Sung Wook Park, Jeong Hun Kim, Seung Hyeok Seok, Jong-Won Oh, and Ho Jeong Kwon. “The Small Molecule R-(-)-β-O-Methylsynephrine Binds to Nucleoporin 153 kDa and Inhibits Angiogenesis.” Int J Biol Sci. (2015).
Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515819/
- Pawar RS, Grundel E. “Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs).” Drug Test Anal. (2017 Mar). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/27259162
John has been a fitness enthusiast for over 10 years, starting out while struggling with obesity as a teenager. Over the years he has advised numerous clients on how to transform their physiques and their lives. As a writer on Nutrition Inspector he aims to help others achieve real results by staying clear of the common hype and false claims in the supplement industry!