Formulated and created by Lazarus Labs, Phentramin-D is an over-the-counter option for those who want to bypass the prescription weight loss pill Phentermine. Phentramin-D is made to suppress appetite with its clinically designed ingredients. Lazarus Labs claims that the effects of Phentramin-D were once only available through prescriptions, but with new pharmacological research, they made it available for everyone.
Phentramin-D is intended to burn fat and raise metabolism using its powerful ingredients. It claims to help people safely lose weight every single day while getting rid of actual body fat and not just water weight. Increased energy levels and reduced appetite are also some of the benefits.
So is Phentramin-D truly an efficient solution for weight loss? Is this stimulant formula safe? In this unbiased review, you’ll learn the truth behind this supplement. Just read on!
As with many shady weight loss supplements, Phentramin-D also comes in the form of a proprietary blend. Consumers are not informed about the specific dosages for each ingredient found in the product.
However, here is the list of ingredients included in Phentramin-D:
- Yohimbine HCL – Is a strong stimulant that affects the nervous system and fat tissue. Yohimbine HCL has the ability to specifically target stubborn fat (1). Fat cells have two different receptors that control it, alpha-2 receptors and beta-2 receptors. Yohimbine HCL blocks the alpha-2 receptors, allowing the body to burn off the stubborn fat easier. An important thing to note is that research actually backs up these claims. However, Yohimbine has been linked to some severe side effects. These include irregular or rapid heartbeat, kidney failure, seizures, heart attack, and others (2).
- 2-Phenylethylamine (PEA) – While this compound has no significant effect on body composition, it still provides some health benefits (3). 2-Phenylethylamine HCL is also known as the “love drug”, and has the ability to stimulate the transmission of the amino acid phenylalanine which induces positive and stable mood levels. Also present in chocolate, this ingredient could increase dopamine production in the pleasure points of the brain, promoting happiness and satisfaction (4).
- Hordenine – Is a natural chemical that occurs in a number of different plants such as barley grass and cactus (5). Hordenine is commonly used as a nootropic that works to improve cognition, stimulate higher energy levels and improve mood. Recent research suggests that it can also suppress appetite (6).
- 1,3.7 Thimethylxanthine – Is just a fancy name for Caffeine. This ingredient is pretty self-explanatory and widely known. It’s not a coincidence that most diet pills include Caffeine in their formula. Caffeine is clinically proven to boost energy levels and reduce fatigue, which is why it is the staple ingredient in most pre-workout supplements (7). It allows the user to stay focused and energized throughout any physical activity, creating the best possible results. However, the slight concern is the unknown amount of Caffeine found in Phentramin-D. Higher doses of Caffeine can lead to insomnia, nervousness and restlessness, stomach irritation, nausea, and vomiting (8).
- Synephrine – This compound is known for its weight reduction and energy boosting properties (9). However, recent studies go against Synephrine, concluding no significant weight changes in the participants who were tested. Unfortunately, there is even more bad news. Synephrine has been reported to induce a number of serious side effects. It has been banned in many countries following the side effects issue (10) (11).
Phentramin-D combines a number of potentially dangerous stimulants together. Each of these compounds alone can potentially induce adverse effects. Without knowing the full amount of each ingredient, it’s virtually impossible to properly dose this product according to one’s own needs.
Due to the possibility of dangerous side effects, the kind of ingredients found in Phentramin-D are not long-term solutions for weight loss.
Also, there is no information available that would show what these compounds might do to the body when they are mixed together. Lazarus Labs fail to provide any information about how they tested this dietary supplement if it even went through any testing.
To take Phentramin-D, users are recommended to take one capsule or pill 20 minutes before breakfast, and another one 20 minutes before lunch with plenty of water. Lazarus Labs recommends every user combine Phentramin-D with a proper diet plan and exercise program. They also indicate potential smaller side effects, not mentioning the real dangers of their ingredients.
“I purchased my product based on customer reviews on their website and was completely disappointed with this product. I followed the directions diligently and lost no weight. I actually gained a few pounds. I did not change my diet in any way and continued with my daily exercise routines. Needless to say, this product was very disappointing.” -Amy Cabassa
“I don’t see how this product suppresses my appetite at all, in fact, I feel it has increased my appetite and there is no increased energy. I’m more tired than ever.” -Howard Smith
“I was told it was okay to take it even though I had high blood pressure. Before I knew it, I was becoming dizzy and felt that the world was spinning. I never managed to lose even one pound of weight due to the pill. But I did lose weight, because I felt nervous and dizzy, and did not want to eat. It kept my stomach upset as well. If you have high blood pressure or acid reflux, please do not take this medication. It also made my acid reflux worse. When I was walking everything in front of me was curving around. I could not even see straight.” -Alexandra Love
Before making a final decision on Phentramin-D, it’s essential to look at the company behind it, the customer reviews, and the kind of evidence that’s provided. The manufacturers fail to offer any real scientific research that would prove the effectiveness of their proprietary blend. Also, none of these ingredients have been proven to be both safe and effective.
Many customers have also failed to see any benefits at all. But the definite deal breaker for Phentramin-D is its numerous potential side effects. These negative effects can have serious long-term consequences on the body. With the variety of weight loss supplements available today, you are better off finding a different product.
- Ostojic SM. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Res Sports Med. (2006 Oct-Dec). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/17214405
- Shahin Akhondzadeh, Afshar Amiri, and Amir Houshang Bagheri. “Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial.” Iran J Psychiatry. (2010 Winter). Viewed at:
- Meredith Irsfeld, Matthew Spadafore, and Dr. Birgit M. Prüß. “β-phenylethylamine, a small molecule with a large impact.” Webmedcentral. (2013 Sep 30). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904499/
- A Szabo, E Billett, and J Turner. “Phenylethylamine, a possible link to the antidepressant effects of exercise?” Br J Sports Med. (2001 Oct). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1724404/
- Kim SC, Lee JH, Kim MH, Lee JA, Kim YB, Jung E, Kim YS, Lee J, Park D. “Hordenine, a single compound produced during barley germination, inhibits melanogenesis in human melanocytes.” Food Chem. (2013 Nov 1). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/23768344
- Thomas Sommer, Harald Hübner, Ahmed El Kerdawy, Peter Gmeiner, Monika Pischetsrieder, and Timothy Clark. “Identification of the Beer Component Hordenine as Food-Derived Dopamine D2 Receptor Agonist by Virtual Screening a 3D Compound Database.” Sci Rep. (2017). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345022/
- Jennifer L. Temple, Christophe Bernard, Steven E. Lipshultz, Jason D. Czachor, Joslyn A. Westphal, and Miriam A. Mestre. “The Safety of Ingested Caffeine: A Comprehensive Review.” Front Psychiatry. (2017). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445139/
- Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A, Feeley M. “Effects of caffeine on human health.” Food Addit Contam. (2003 Jan). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/12519715
- Ratamess NA, Bush JA, Kang J, Kraemer WJ, Stohs SJ, Nocera VG, Leise MD, Diamond KB, Faigenbaum AD. “The effects of supplementation with P-Synephrine alone and in combination with caffeine on resistance exercise performance.” J Int Soc Sports Nutr. (2015 Sep 17). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/26388707
- Sidney J. Stohs, Harry G. Preuss, and Mohd Shara. “A Review of the Receptor-Binding Properties of p-Synephrine as Related to Its Pharmacological Effects.” Oxid Med Cell Longev. (2011). Viewed at:
- Stohs SJ, Preuss HG, Shara M. “A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine.” Int J Med Sci. (2012 Aug 29). Viewed at:
Amanda is a gym instructor and a diet and nutrition fanatic that has reviewed 100s of supplements for the benefit of consumers. She struggled with obesity 7 years ago and after losing more than 30lbs, dedicates most of her time in helping others achieve similar results and transform their lives.