Phendimetrazine is a weight loss supplement that serves as a thermogenic or fat metabolizer. This diet pill is mostly oriented towards highly obese and overweight people. It’s only intended for short-term use and only a doctor can prescribe it. The product itself works with other factors to ensure complete weight loss success. It claims to trigger thermogenesis, increase the metabolic rate, leading to a significant decrease in the weight of the user.
But we've all heard these promises before, promises full of positivity and extraordinary claims. The real question is how much truth is behind them? In this review we will carefully inspect Phendimetrazine, figuring out the real potential of this weight loss supplement. Just read on and see!
How Does Phendimetrazine Work?
Phendimetrazine is a diet pill with similar properties to an amphetamine. This diet pill stimulates the central nervous system and helps to release adrenalin, epinephrine, and dopamine. It should also raise the heart rate and blood circulation while helping to reduce the desire for and hunger for food.
With its thermogenic properties, it can increase the body’s temperature, resulting in a faster metabolism even at rest. Thermogenesis literally means heat escalation. It promotes the burning of excess calories to produce heat, this process naturally occurs in warm-blooded organisms (1).
Phendimetrazine contains both active and inactive ingredients. The product comes in two variants. One variant contains 35mg of Phendimetrazine Tartrate which is the main ingredient, and the second one includes 105mg. Depending on the variant, each capsule is absorbed differently. The 35mg capsule is released instantly, whereas the Phendimetrazine 105mg capsule is a slow release one.
Active Ingredients Include:
- Phendimetrazine Tartrate – Is a sympathomimetic amine, a compound identical to amphetamine. Phendimetrazine Tartrate is generally used in short-term treatment of obesity (2). This anorectic stimulates the nervous system and brain, which increases your heart rate and blood pressure, and decreases appetite. It’s highly advisable to seek medical attention before using this compound. Using this substance for too long or suddenly stopping it has clinically shown to cause potentially serious side effects (3). People who suffer from heart or thyroid problems, sensitivity to stimulants and certain allergies are advised to stay away from Phendimetrazine Tartrate. Possible side effects include overstimulation, jitters, insomnia, agitation, tremors, sweating, dizziness, psychotic behavior, blurred vision, fainting, flushing, diarrhea, constipation, nausea, changes in libido, and dry mouth (4). These are just some of the possible side effects, there are even more! Detailed analysis also shows that weight management with this compound is not even guaranteed. The US government also states that Phendimetrazine Tartrate has a potential for abuse and that it may lead to moderate or lower physical dependence or high physiological dependence (5).
Inactive Ingredients Include:
- Povidone – This polymer has a sole purpose of making the ingredients found in Phendimetrazine less taxing on the body. Mixed with Iodine, Povidone can form a powerful antiseptic (6).
- FD&C Blue No.1 – Is a synthetic food dye often added to processed foods, beverages, soaps, and shampoos. The body has a hard time absorbing this additive, and often it will show up in the actual stool of the consumer. Unfortunately, this additive contains a number of potential adverse effects. The FDA also stated the potential toxic properties of this food coloring agent (7).
- FD&C Red. No. 40 – This artificial food coloring agent has been found to potentially induce ADHD (Attention Deficit Hyperactivity Disorder) and DNA damage. Studies have even found that Red. No. 40 has potential carcinogenic abilities, and for this reason, health organizations have tried and are still trying to ban its use (8).
- Silicon Dioxide – Silica has the role of an anti-clumping agent, which prevents the Phendimetrazine pills from sticking together. Silica also ensures that there is an even distribution of the active ingredient throughout the mix (9).
- Sodium Lauryl Sulfate – Is a detergent and foaming agent, usually found in shampoos, toothpaste, and soaps. Some people can experience irritations after the use of Sodium Lauryl Sulfate (10).
Other Ingredients include Sucrose, Talc, Shellac, Gelatin, and Corn Starch.
There is just 1 active ingredient out of 11. The rest are filler additives and coloring agents which are only added to coat the pills, give them color, and to make them absorbable.
The sole active ingredient has been shown to be potentially harmful even when prescribed by a doctor. There is also no assurance of its safety or weight loss benefits.
Another issue is the additives, such as food colorings, that have been found to possess possible toxic and allergic effects.
The overall quality of ingredients is poor since they can be extremely dangerous and inefficient for weight loss. There’s no long-term assurance that any weight won’t come back.
Research Related to Phendimetrazine
A study concluded by the National Library of Medicine stated that Phendimetrazine should only be taken for three to six weeks and that it should be discontinued when the user no longer feels any suppressant effects. They also mentioned the highly addictive properties of Phendimetrazine, which could lead to insomnia, irritability, increase heart rate and psychosis (11).
Other controlled studies compared Phendimetrazine diet pills and placebo pills. The difference in weight loss was almost unnoticeable at just a half a pound a week. They also concluded that Phendimetrazine diet pills will stop working after a couple of weeks after the body gets used to their stimulatory properties and develops a tolerance (12).
We also need to mention, the US government considers Phendimetrazine a schedule 3 drug which means that it has a potential for abuse and may lead to dependence. It is also listed under schedule III by the U.S Controlled Substance Act in the 2007 Drug Identification Bible.
Before we make a final decision on Phendimetrazine, it’s important to go over the possible side effects, user experiences, and the general kind of effects. The people who have reviewed this brand say it’s ineffective and unsafe.
There is no guarantee that it will actually work, and diet and exercise also have to be added. Still, a doctor’s prescription is required for the key active ingredient, and it could only be a short-term solution for appetite suppression. Long-term use of this supplement can lead to fatal consequences and possible addiction.
Taking everything into consideration, the market is full of safer and more effective diet pills that will surely provide better results at a minimal risk.
- Villablanca PA, Alegria JR, Mookadam F, Holmes DR Jr, Wright RS, Levine JA. “Nonexercise activity thermogenesis in obesity management.” Mayo Clin Proc. (2015 Apr). Viewed at:
- Jianzhong Xiao and Wenying Yang. “Weight Loss Is Still an Essential Intervention in Obesity and its Complications: A Review.” J Obes. (2012). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395150/
- Müller FO, Hundt HK, Gosling JA. “Availability of phendimetrazine from sustained and non-sustained action formulations.” S Afr Med J. (1975 Feb 1). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/1173199
- Susan Z. Yanovski, M.D. and Jack A. Yanovski, M.D., PhD. “Long-term Drug Treatment for Obesity: A Systematic and Clinical Review.” JAMA. (2014 Jan 1). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928674/
- Gomez G, Stanford FC. “US health policy and prescription drug coverage of FDA-approved medications for the treatment of obesity.” Int J Obes (Lond). (2017 Nov 20). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/29151591
- Angela M. Leung and Lewis E. Braverman. “Consequences of excess iodine.” Nat Rev Endocrinol. (2014 Mar).
Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976240/
- Junjie Wang, David George Jackson, and Gerhard Dahl. “The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1.” J Gen Physiol. (2013 May). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639576/
- Richfield-Fratz N, Bailey JE Jr. “Determination of p-cresidine in FD&C red no. 40 by the diazotization and coupling procedure followed by reversed-phase high-performance liquid chromatography.” J Chromatogr. (1987 Sep 18). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/3693468
- Villota R, Hawkes JG. “Food applications and the toxicological and nutritional implications of amorphous silicon dioxide.” Crit Rev Food Sci Nutr. (1986). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/3011357
- Cara AM Bondi, Julia L Marks, Lauren B Wroblewski, Heidi S Raatikainen, Shannon R Lenox, and Kay E Gebhardt. “Human and Environmental Toxicity of Sodium Lauryl Sulfate (SLS): Evidence for Safe Use in Household Cleaning Products.” Environ Health Insights. (2015). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651417/
- Kyoung Kon Kim, Hi-Jung Cho, Hee-Cheol Kang, Bang-Bu Youn, and Kyu-Rae Lee. “Effects on Weight Reduction and Safety of Short-Term Phentermine Administration in Korean Obese People.” Yonsei Med J. (2006 Oct 31). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687747/
- Matthew L Banks, Bruce E Blough, and S. Stevens Negus. “Effects of 14-day treatment with the schedule III anorectic phendimetrazine on choice between cocaine and food in rhesus monkeys.” Drug Alcohol Depend. (2013 Aug 1). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713102/
Emily has spent the last 8 years comparing, reviewing and analyzing ingredients in the supplements industry. She has worked extensively with dieticians, nutritionists and personal trainers to separate fact from fiction and help people achieve their fitness goals. In her free time she works and enjoys the outdoors with her husband and 2 children.