Lipodrene is a thermogenic supplement that was developed by Hi-Tech Pharmaceuticals and marketed as revolutionary.
With the product's packaging featuring the words ‘most advanced weight loss aid ever’, it might be time to find out how useful these little yellow hexagonal pills prove to be.
Lipodrene claims to suppress appetite, burn fat and boost metabolism. In this sense, it makes the same claims as many other weight loss supplements on the market.
Very little about the supplement stands out, but its producer Hi-Tech Pharmaceuticals must be getting something right because this supplement has been on the market (presumably at a profit) for more than fifteen years.
Hi-Tech Pharmaceuticals is a CGMP certified company, meaning that it abides by good manufacturing processes established by the FDA. It’s important to remember this says nothing about the efficacy of Lipodrene itself, however: it assures us that the product is made in a safe manner and you can expect to get what you see on the bottle.
What does it do?
Lipodrene claims to help people lose weight via several routes. The ingredients in the supplement are all presented as having different and crucial functions in the reduction of fat, an increase in energy levels and suppression of appetite.
The main action of this product is marketed as the stimulation of lipolysis and inhibition of lipogenesis. If Lipodrene is successful in doing this, it would make sense that it would provide consumers with a more desirable number when they step onto the scales.
Increase utilization and release of energy from fat stores in the body, alongside decreased storage of excess energy and synthesis of new fat, is a recipe for success. However, it is a lofty promise and we’ve seen plenty of hyperbole on the market.
The process supposedly works by preventing the release of targeted enzymes that control fat storage while stimulating processes that result in energy store utilization and the breakdown of unwanted excess fat.
For the product to have this effect, it would have to contain a specialized biological catalyst that would target this specific metabolic pathway.
Evidence: What’s in it?
Let’s start by pointing out an obvious factual discrepancy. The manufacturer of Lipodrene claims it induced its actions by binding to alpha-2 receptors. As they fail to mention what in the pill binds to these receptors (let’s hope we’re not expected to believe the pill itself binds to them), we took a closer look at the ingredients to find out.
- Ephedra Extract
- Senegalia Berlandieri Extract
- Phenylethylamine HCl
- Synephrine HCl
- Green Tea Extract
- Hoodia Extract
- Extend-Rx technologies 560mg
Not one of these ingredients would in fact bind to an A2-adrenoceptor , so we’re concerned this is more of a marketing ploy than a real benefit.
Ephedra is a plant-based herb that was originally procured for curative properties in Chinese medicine. Ephedra is a powerful stimulant and didn’t take much for this herb to become very popular in the fitness industry .
The supplementation of Ephedra was investigated by the FDA in 2004 through the ban of Ephedrine Alkaloids. The ban was necessitated due to many manufacturers and consumers ignoring and exceeding recommended dosages, quickly leading to dangerous side effects .
Ephedra is now making a return to the mainstream supplement industry. Through the removal of Ephedrine Alkaloids, supplement companies are still able to produce and sell Ephedra extract. The extract is also much easier to regulate and strict regulations on Ephedra dosages are now more heavily enforced. We still recommend caution, and this product might not be suitable for those with a low stimulant tolerance – especially with so many examples of over-dosing .
As mentioned previously, the herb is a stimulant that can cause heart attacks and angina, irregular heartbeat, and high blood pressure . Ephedra can also cause other problems from tremor and seizure disorders to thyroid and adrenal problems. It might be wise to avoid this extract if you have any pre-conditions.
Phenylethylamine is an analog to amphetamine, though the effects are milder by comparison. It is a nervous stimulant, similar to ephedra and amphetamine, but it produces lesser effects – both beneficial and detrimental.
Phenylethylamine is a drug we’re conflicted on. It has some excellent long-term benefits for the nervous system when supplemented in very small doses, including improvements in the Acetyl-Choline release, but it is another stimulant in a very stimulant-dominant supplement.
We prefer phenylethylamine in the absence of ephedrine, as the two combined seem to pose a serious chance of negative ramifications for some users. Caution and attention to your health is our prescription here, as Phenylethylamine is a risky but suitable stimulant by itself.
Extend-Rx Technologies 560mg
We’re skeptical of proprietary blends for a reason: we don’t know how much of each compound is present which makes it hard to say whether it is safe or effective, or not.
Senegalia Berlandieri Extract
Which can more accurately be called Acacia Berlandieri. Familiar. Research has provided evidence that dietary supplements labeled as having the active ingredient Acacia are usually incorrect.
Testing by the FDA has revealed that of 21 Acacia supplements tested, not a single one was found to contain any compounds that chemically resembled Acacia extract. Instead, what these products were found to contain is a synthetic stimulant called BMPEA (beta-methylphenethylamine) .
BMPEA has a chemical structure that closely resembles that of amphetamine, leading to the suggestion that it will have similar effects on the body. BMPEA is considered a “doping agent” by the World Anti-Doping Association [8a] and has been highlighted in case studies as a key player in hemorrhagic stroke [8b].
Anhydrous Caffeine, Green Tea Extract, and Theobromine
Three ingredients sourced from high-caffeine plants .
We all know caffeine: it’s fine in small doses but can be harmful if doses aren’t controlled. The inclusion of three separate sources of the stimulant, in a supplement that already contains a large stimulant load, is perplexing .
Theobromine is one of the very few ingredients in this product that we wholeheartedly recommend. It is the main compound linked to positive health in chocolate and red wines and can reduce blood pressure and the associated risks of heart attack/failure.
It might not be enough to offset the stimulant risk factors, but these 3 ingredients are effective and healthy.
Synephrine HCI 25mg
Overview: Does it work?
Hi-Tech Pharmaceuticals markets Lipodrene as a metabolic enhancer, appetite suppressant and potent fat bringing brand.
These claims are, at face value, correct. The problem is that their effectiveness is only possible as a result of compounds that tend to have high rates of side-effects and can contribute in a major way to existing heart and digestive problems.
The sad truth about fat-burning supplements is that most of the effective compounds are unhealthy and most of the healthy compounds are largely-ineffective. Lipodrene opts for the former and the stimulant load is a real concern: it should be weighed carefully against your own health situation and needs.
At least one Lipodrene lawsuit has previously been filed, including a class action, for misrepresenting effectiveness [11a] and mis-labeling products [11b].
Due to a shady reputation and high stimulant-load, there is a serious question about effects vs health for this product. We can say beyond a doubt that it will improve metabolism and induce greater weight loss if diet and activity do not change. This does not mean, however, that it is worth it. That is a decision for you, the consumer, to consider.
Remember that healthy weight loss is the only kind worth chasing and that supplements should foster a healthier, happier you.
 Hoffman, Brian B., et al. “Alpha-adrenergic receptor subtypes: quantitative assessment by ligand binding.” Life sciences24.19 (1979): 1739-1745.
 Astrup, Arne, et al. “The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial.” International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity 16.4 (1992): 269-277.
 Boozer, C. N., et al. “Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial.” International Journal of Obesity 26.5 (2002): 593.
 White, Laura M., et al. “Pharmacokinetics and cardiovascular effects of ma‐huang (Ephedra sinica) in normotensive adults.” The Journal of Clinical Pharmacology 37.2 (1997): 116-122.
 Berman, Jeffrey A., et al. “Complicated hypertension related to the abuse of ephedrine and caffeine alkaloids.” Journal of addictive diseases 25.3 (2006): 45-48.
 Wadden, Thomas A., et al. “The Fen‐Phen Finale: A Study of Weight Loss and Valvular Heart Disease.” Obesity 6.4 (1998): 278-284.
 Eichner, Sara, et al. “Banned and discouraged-use ingredients found in weight loss supplements.” Journal of the American Pharmacists Association 56.5 (2016): 538-543.
[8a] Chołbiński, Piotr, et al. “Detection of β-methylphenethylamine, a novel doping substance, by means of UPLC/MS/MS.” Analytical and bioanalytical chemistry 406.15 (2014): 3681-3688.
[8b] Cohen, Pieter A., et al. “Hemorrhagic stroke probably caused by exercise combined with a sports supplement containing β-methylphenyl-ethylamine (BMPEA): a case report.” Annals of internal medicine 162.12 (2015): 879-880.
 Westerterp‐Plantenga, Margriet S., Manuela PGM Lejeune, and Eva MR Kovacs. “Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation.” Obesity 13.7 (2005): 1195-1204.
 Faraone, Stephen V., and Timothy E. Wilens. “Effect of stimulant medications for attention-deficit/hyperactivity disorder on later substance use and the potential for stimulant misuse, abuse, and diversion.” The Journal of clinical psychiatry 68 (2007): 15-22.
Amanda is a gym instructor and a diet and nutrition fanatic that has reviewed 100s of supplements for the benefit of consumers. She struggled with obesity 7 years ago and after losing more than 30lbs, dedicates most of her time in helping others achieve similar results and transform their lives.