Our first impression of Dr Sinatra’s Omega-3 slim (Omega slim hereafter) leaves us with 2 real points to make. Firstly, putting “Dr” in the name of your supplement is a fab marketing tool – it really makes it seem like the product is going to be effective and safe whether it is or not. So remember, doctors are people too and their medical license doesn’t mean they won’t try and break into the supplement market for good or bad reasons.
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Secondly, and we’ll be discussing this further in the article, it is important to take a cautionary view of new technologies. Whilst the field of nutrition and food science is making large and impressive developments lately, we have to be careful when looking at the effectiveness of new technologies, especially those that have not yet been exposed to a large amount of scientific scrutiny. When we see the corporate sponsorship of these new technologies – and no independent study – it is important to be skeptical.
What is it?
Omega slim is a dietary aid supplement that has 3 main components. We’re going to discuss all of them today: Phytosomal EGCG (a chemically altered form of green tea extract), Calamarine: a fancy omega-3 oil (primarily EPA and DHA) and Crominex (a chromium supplement). Overall, the product claims to be able to improve weight loss to 200% of regular rates whilst also boosting heart health and regulating blood sugar. These are some large claims and we’ll be using this article to discuss the benefits of the individual ingredient, the efficacy of the product overall and where it fits into the market compared to alternatives.
EGCG is a common and genuinely-effective compound found in green tea and its extracts. This is one of the group of compounds known as “green tea catechins” and has been linked to the increased oxidation of fat, improved development of “brown” fat (the kind that is metabolically active) and possesses potent antioxidant properties . The “liposoma” is simply a small spherical fat carrier for the EGCG – these are an emerging technology that reduces the breakdown of chemicals during digestion, meaning that we get more EGCG in the body without consuming more.
EGCG has been shown to be incredibly effective at improving fat metabolism and reducing cell damage risks in vitro, with slightly less effectiveness when consumed. This suggests to us that the process of digestion is one of the most problematic areas for EGCG – it is often destroyed or denatured during the digestion process, making regular oral consumption less effective . The introduction of a liposoma (or phytosoma, in this case) may reduce this problem and make it a more effective compound for weight loss and promoting health.
The problem that we have with the use of liposomal EGCG Is not that it doesn’t work – we have a wealth of literature on the effectiveness of EGCG in vitro and in vivo . Rather, we have concerns over the effectiveness claimed by Omega slim and the clinical studies that are used in support [3, 4] – 200% effectiveness over regular weight loss (even with non-liposomal EGCG consumption) is a huge claim and requires equally huge clinical support.
Whilst the experimental design of Omega slim’s supporting evidence is superficially impressive, some studies suggest that the liposomal binding of EGCG is not as effective as other catechins , whilst even in vitro studies suggest that the effectiveness of EGCG on fat loss would not be 200% [1, 6]. It is not impossible – but very unusual – for fat oxidation and energy metabolism to be higher in vivo than in vitro , so we have some theoretical concerns about the plausibility of Omega slim’s claims. Overall, we’re eager to see an expansion in the literature – we know that there are positive effects of EGCG and the liposomal delivery does provide a mechanism for improved effectiveness, but probably not to the degree claimed in these clinical studies.
There’s no debate on this issue: Omega-3 fatty acids are fantastically healthy for humans, as well as being essential fats. This means that we need them because they are beneficial, but also because they cannot be synthesised in the human body – diet and supplementation are the only way to get the right amount of Omega-3 into the body. The main benefits of this are improvements in blood lipids, regulation of blood sugar, reduced general inflammation, hormonal health, metabolic regulation and numerous others .
Calamarine is a “unique” omega-3 complex extracted from squid – unique perhaps only for the concentrations of DHA found in this form of omega-3. DHA is the longest-chain form of Omega-3 and has some of the most potent effects, being able to be converted to ALA and EPA more easily than the reverse. They are also more responsibly produced than regular fish oil – reducing the need for fish farming. Calamarine may still be omega-3, but it is definitely a top-quality product and adds to the quality and value of Omega slim overall.
As to whether there are extra fat loss benefits to Calamarine that are not present in other forms of fish oil (such as cod liver), we can’t be sure. The conversion of fish oils and the dosages present in the product make it likely that increased DHA is better for health, but the effects on fat loss between cod liver oil and calamari/squid oil are negligible.
Chromium is an essential mineral – something that we can’t create from other foods or chemicals within the body. It is involved in the regulation of blood sugar and the metabolism of glucose, making it an important part of Omega slim’s approach to improving blood and heart health, as well as being particularly important to those who suffer from type-2 diabetes. Crominex claims to be a more bioavailable form of chromium, with Chromium being a notoriously low-absorption mineral. Absorption rates are actually as low as 0.8-1% in humans.
Crominex, however, claims to be more bioavailable than other forms of chromium. It is a Chromium-3 compound, a form of chromium that was previously believed to be superior at absorption. Previously is the operative word here: chromium-3 appears to only be more bioavailable than other forms in rodent populations (up to 2200% more available), but had no greater bioavailability in humans than other forms. This does something to dampen our enthusiasm about Crominex as a superior form of chromium, though it is still very positive to see chromium being used as a health and blood sugar regulation supplement.
Despite the positive effects on insulin regulation and blood sugar improvements, there do not appear to be any scientifically-verified positive effects on weight loss, even among those suffering from Type-2 diabetes. We don’t feel the need for all ingredients to be specifically aimed at weight loss – Omega slim aims at improved health across the board – though it is important to note that 2/3 of the ingredients in “omega slim” do not have active fat loss effects.
The practical stuff: market alternatives and pricing
We need to look at this product in light of its constituents and their market alternatives. Green tea catechins are present in countless supplements and have a variety of price points. We can buy such catechins – with good concentrations of EGCG – for as little as $5-8. Equally, we can buy fish oil for around $5-10 a month, but calamari oil will generally be more expensive. The cost of a chromium supplement will be an additional $7-10. Overall, it is clear that this product is good value for money – it is likely to be around the same price or cheaper than less effective market alternatives. This makes for another excellent reason to try the product for yourself.
The effects of Omega slim are had to discuss conclusively: the most controversial – and effective – ingredient is liposomal EGCG. This is controversial and we are uncertain about it due to the lack of independent studies, and studies in general. There is a distinctive lack of corroborating in vivo evidence surrounding the usefulness of this compound, as well as some conflicting theoretical explanations of the upper limitation for EGCG on fat loss.
Overall, we are fans of this product. Whilst there are still flaws in the conception of the product and some concerns over the clinical evidence, it provides an improved mechanism for the provision of an indisputably-effective compound as well as various other essential nutrients. Whilst we cannot speak to the fat loss effects of the product, we do believe that there are some important health benefits that can be gained.
Given the price point, especially relative to other market alternatives, we recommend giving this supplement a try in order to improve general health. From there, we’d recommend an open mind about the possibilities of fat loss benefits – whilst the evidence remains inconclusive, it is an inexpensive supplement and could improve fat loss above and beyond conventional EGCG supplementation. Overall, we’d give this product a 3.5 out of 5: if future scientific research substantiates the claims it makes of lipo/phytosomal EGCG then this could quickly become a 5/5!
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 Kao et al (2000): ‘Modulation of obesity by a green tea catechin’. American journal of clinical nutrition, 72(5), pp.1232-1233
 Hursel et al (2011): ‘The effects of catechin-rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis’. Obesity reviews, 12(7), pp.573-581
 Hashimoto et al (1999): ‘Interaction of tea catechins with lipid bilayers investigated with liposome systems’. Bioscience, biotechnology and biochemistry, 63(12), pp.2252-2255
 Dulloo et al (1999): ‘Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-hour energy expenditure in humans’. American journal of clinical nutrition, 70, pp.1045-1050
 Regis et al (2005): ‘In vitro and in vivo’. Proceedings of the national academy of science [URL = http://www.pnas.org/content/suppl/2005/06/24/0409553102.DC1/09553SuppTextFIXED.pdf]
John has been a fitness enthusiast for over 10 years, starting out while struggling with obesity as a teenager. Over the years he has advised numerous clients on how to transform their physiques and their lives. As a writer on Nutrition Inspector he aims to help others achieve real results by staying clear of the common hype and false claims in the supplement industry!