Biotrust is a fairly well known supplement company that started operating in 2012, they are a difficult company to investigate because googling their name gives you about 50 fake review websites. This always puts me on edge because if your product was so good why would you need a fake website titled “Biotrust Exposed”? Irritating.
But fake websites aside, what are the products like? Leptiburn is a fat-burning pill that claims to “Increase Leptin production and sensitivity, support accelerated fat loss, and diminish weight loss plateaus”. You are supposed to take 2 capsules per day and each $69 bottle contains 60 capsules, for this money Leptiburn better be very effective!
Think what that $69 per month could be spent on instead? High protein meals, a personal trainer session, some decent whey protein. Leptiburn has positioned itself as an effective product and is charging a high price because of this. With this in mind, let's delve into the ingredients list to see how effective they are.
Before doing that however, we should have a look at what Leptin is as Leptiburn is clearly basing their marketing around their ability to burn fat with it. Leptin is a hormone produced by fat cells (or adipose cells if you're trying to sound fancy) that works alongside another hormone called Ghrelin to regulate appetite.
While Ghrelin's job is to send messages to your brain that you are hungry, Leptin's job is to tell the brain that you are full. When both hormones are working well you will be able to achieve an energy balance and neither gain or lose weight. Lowering your calories to lose weight will involve increased signalling from Ghrelin as your stomach will be empty more often than usual.
The belief for quite a while was that Obese people had lower levels of Leptin which made them eat more, this led to the Supplement industry flooding the market with Leptin-based products. But actually Obese people have “high levels of circulating leptin” in their blood  and increasing Leptin has been shown to have no effect on Obesity .
The reason for this seems to be that rather than having lower levels of Leptin that require ‘topping up' with supplements Obese people suffer from Leptin resistance. This means that the Leptin signals to the brain are being disrupted, and this can be caused by increased body fat, a vicious circle.
What this means is that, while Leptin does play a huge part in weight management increasing production of Leptin will not lead to Fat loss. The best way to fix Leptin resistance is to lose body fat which should prevent the Leptin signals from being disrupted.
So if Leptiburn lowers body fat, it will technically be improving Leptin … Just not in the way they claim.
Olive Leaf (150mg per serving) – Olive leaf extract seems to be an interesting ingredient, as Examine.com puts it “Although olive leaf has been implicated in various fat burning effects (increased thyroid hormones and adrenaline) there does not appear to be any overall fat lost in trials using olive leaf supplements” . They believe that the reason for this is that the receptor levels for Adrenaline may decrease preventing any benefits.
A good way of summing Olive Leaf Extract up is that it could help fight obesity but no studies have actually seen any significant results in terms of fat-loss so far (in humans) . The dosage seems to be about right and there are other potential benefits to OLE such as decreased blood pressure and lowering of cholesterol .
Brown Seaweed (200mg per serving) – Also known as Bladderwrack, brown seaweed is thought to increase thermogenesis due to a compound it contains that is known as Fucoxanthin. But due to the very low levels of Fucoxanthin contained in Brown Seaweed the effect is almost certainly negligible. It contains high levels of Iodine which is necessary for proper Thyroid function. As a fat-loss ingredient, Brown Seaweed is a pretty poor ingredient, but it could help prevent Goitre so that's a plus.
Irvingia Gabonensis (150mg per serving) – Irvingia Gabonensis is a seed from the African Mango that could help decrease fat mass, but as Examine.com points out the study that found this  was funded by the manufacturer of Irvingia Gabonensis. That doesn't necessarily mean we should discount their findings, but we should be sceptical particularly as there are so few studies around. What the study found was that taking IG prior to eating resulted in a lower calorie intake, which led to fat loss. You could quite easily recreate these results with a pint of water too!
Panax Notoginseng (400mg per serving) – Panax Notoginseng or Ginseng as it is more commonly known. Ginseng has many proven benefits; it reduces blood glucose, increases cognition, and may improve sleep quality. It does not appear to have any effect on fat-loss, increased Testosterone, or weight loss though.
Green Tea (350mg per serving) – Green tea extract can increase fat-loss but the results are not only unreliable, but they are barely significant . Green tea might possibly increase fat-oxidation (the burning of fat for energy) but again there isn't enough evidence to support this, and it only seems to affect people who don't consume caffeine regularly. There are however a whole host of other benefits to Green tea and it has been used in alternative medicine for Centuries.
Yerba Mate (83mg per serving) – Yerba Mate is essentially caffeine, and there are many benefits to taking caffeine. Supplementing with Caffeine can increase metabolism and fat-oxidation  and increase 24-hour energy expenditure , it also can improve performance . However to get the benefits of caffeine you need to be taking enough Yerba Mate, and this product is woefully short of the amount required. Most of the studies that found Yerba Mate to be successful as a fat burner used between 1,000mg and 2,000mg of Yerba Mate , whilst the maximum amount of Yerba Mate you will get from this product is less than 400mg (if you took 4 servings).
Leptiburn contains a number of ingredients that could possibly have an effect on body fat levels, however there is nowhere near enough evidence to support most of them (Olive Leaf, Brown Seaweed, Irvingia Gabonensis, Ginseng) and the ones that do have an effect (Green Tea, Yerba Mate) are either in doses that are too low to have an effect, or their effect on fat-loss is barely noticeable.
As mentioned earlier, increasing Leptin production will not have an effect on Obesity as it is most likely that Leptin resistance is the main cause of Obesity, not a lack of Leptin. If this product has any effect on fat loss it will be due to the caffeine content of Yerba Mate. But the levels are low, and will not benefit regular caffeine takers (which has to be most of the population).
This product is at best harmless, and at worst useless. It has a high price tag and a poor selection of ingredients. There are many better products out there that can increase fat-oxidation and lead to weight loss, but even regular caffeine tablets would work.
Worth the money? Not at all
– Mixed. The most popular reviewer on Amazon.com has lost 35lbs in 4 months, and attributes this to cutting back on sweets and taking Leptiburn. Whilst other reviewers have given it 1 star and claim that it made them experience migraines and stomach distress.
In my opinion, none of the ingredients should contribute to migraines or stomach issues but then they wouldn't produce 35lbs fat loss results either. This is the main problem with customer reviews, it is almost impossible to attribute your results to a product when there are so many outside factors to consider.
Did the cutting back of sweets lead to fat-loss or was it the Leptiburn? Perhaps it was a combination of both? Or maybe neither had much of an effect and you lost weight due to an increase in non-exercise activities (walking, cleaning, running for a bus etc …).Way too many variables.
My recommendation: Avoid Leptiburn
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Matt Smith is a fitness and nutrition writer with more than 10 years experience as a personal trainer, and a degree in Sports Science from London Metropolitan University. He has written for many fitness websites, and runs his own blog and podcast at beernbiceps.com