If you’re working out with the goal of creating a muscular and strong physique, supplements are a critical part of your journey and can’t be overlooked.
While there are numerous supplements that should be considered crucial, such as creatine or multi-vitamin supplements, there are also other supplements, that while not essential for good health, can drastically increase the rate at which your body builds muscle mass.
Bio-Gro by iSatori falls into this group and is described as a revolutionary new product that will change the health and fitness industry. This special breed of supplement contains an ingredient called “Bio-active peptides” that is said to significantly boost protein synthesis, which will lead to increased lean muscle growth, decreased recovery time, and sky-rocking strength. The manufacturers even claim that users can gain anywhere from 5 to even 7 pounds of lean muscle mass over the course of only 4 weeks.
These types of claims seem a bit too farfetched, don’t they? To see if iSatori truly created a revolutionary muscle building formula simply continue reading and find out everything you need to know about Bio-Gro!
How is Bio-Gro Intended to Work?
Bio-Gro is primarily formulated to trigger numerous physiological mechanisms in the body that will maximize muscle growth and recovery. The basic idea behind the iSatori theory is that you can consume as much protein as you want, however, it’s not going to be effectively used by the body, which is where Bio-Gro steps in. This product should boost protein synthesis, allowing you to use up the digested protein properly, accelerating lean muscle development which would not be possible otherwise. Not only will Bio-Gro significantly increase the rate at which you build lean muscle mass, but it should also visibly reduce the recovery time between your workouts.
An important factor to be aware of when purchasing a product such as this one is definitely the ingredients. After all, you want to make sure that you are putting safe and effective substances into your body.
Here are the ingredients included in Bio-Gro:
- Proline-Rich Peptides – Proline is a non-essential amino acid that is produced naturally inside the human body (1). The goal of this ingredient is to regulate cell protein synthesis, which would allow the body to use protein more effectively. Unfortunately, studies are still inclusive about its properties (2).
- IGF-1 Insulin-Like Growth Factor – Represents a hormone that has a similar molecular structure to Insulin. It also has identical properties to Insulin since it promotes growth and anabolic effects inside the body (3). Insulin is also the key hormone for weight loss, which is the reason why Bio-Gro might even support weight management (4).
- TGF beta-2 Transforming growth factor-beta 2 – Is a large group of proteins commonly recognized as Cytokines which are known to perform various cellular functions that have a vital role in the embryonic development (5). Cytokines also regulate immune function, inflammation and hematopoiesis (6).
- EGF- Epidermal growth factor – Is a compound that has growth factor properties that stimulate cell growth, proliferation, and differentiation (7). This ingredient is also commonly found in many skin products as it is believed to promote anti-aging (8).
- PDGF- Platelet (Derived growth factor) – Another growth factor that should regulate cell growth and division (9). Studies have not concluded the benefits of this derivative when supplemented (10).
- Immunoglobin G (lgG) – These proteins are crucial for our energy and recovery. Immunoglobin is also especially important for immune health, as it boosts the immune system and speeds up recovery. Immunoglobin G builds antibodies that our bodies don't make on their own so you can fight any potential diseases or health issues (11).
- Lactoferrin – This substance belongs to the innate immune system. Besides its main biological function, namely the binding and transport of iron ions, Lactoferrin also contains antibacterial, antiviral, antiparasitic, catalytic, anti-cancer, anti-allergic, and even radio protecting abilities and functions (12) (13).
- Fibroblast-GF-FGFs – Represent a group of multifunctional proteins that have a wide range of effects (14). Most commonly these proteins have regulatory, morphological, and endocrine effects. They have also alternately been referred to as potential growth factors due to their multiple actions in cell types (15).
Bio-Gro brings a list of ingredients that most of us have never heard of. As far as their effectiveness goes, these ingredients provide more overall health benefits rather than muscle building or fat burning ones. The neuroprotective and immune system enhancing benefits of these compounds are undeniable, so you actually might stand a chance of recovering from workout stress faster. Simply put, there is no concrete scientific proof that would suggest any more expected benefits than the ones we already mentioned.
User feedback is extremely important for these type of products. We get the actual truth about the efficiency and usability of the product.
Generally, most users reported mild muscle gains, with the addition of better workout quality and strength in the gym. Some users also said that they experienced a fuller muscle look right after waking up. However, most benefits reported regarded the faster recovery that Bio-Gro induced. Customers noted a noticeable faster recovery time between each of their workouts, allowing them to be more energized during each session.
At the end of the day, Bio-Gro won’t fulfill all of its claims for sure. This “revolutionary” new supplement has a few potentially solid ingredients and some positive user feedback, however, it’s simply lacking some things that we believe are fundamental. For instance, the manufacturers fail to cite any real unbiased clinical proof, so it’s unknown how this product will affect different individuals.
Bottom line, if you’re fine with only mild muscle building and recovery benefits and simply want to try Bio-Gro, then, by all means, go for it. Just keep in mind that there undeniably more powerful supplement options available on the market today that are capable of real results at a minimal risk.
- Vanhoof G, Goossens F, De Meester I, Hendriks D, Scharpé S. “Proline motifs in peptides and their biological processing.” FASEB J. (1995 Jun). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/7601338
- Serasinghe MN, Seneviratne AM, Smrcka AV, Yoon Y. “Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1.” J Biol Chem. (2010 Jan 1). Viewed at:
- Z Laron. “Insulin-like growth factor 1 (IGF-1): a growth hormone.” Mol Pathol. (2001 Oct 18). Viewed at:
- Nicole M. Ashpole, Jessica E. Sanders, Erik L. Hodges, Han Yan, and William E. Sonntag. “GROWTH HORMONE, INSULIN-LIKE GROWTH FACTOR-1 AND THE AGING BRAIN.” Exp Gerontol. (2015 Aug 6).
Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388761/
- McLennan IS, Koishi K. “Transforming growth factor-beta-2 (TGF-beta 2) is associated with mature rat neuromuscular junctions.” Neurosci Lett. (1994 Aug 15). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/7824170
- Pakkanen R. “Determination of transforming growth factor-beta 2 (TGF-beta 2) in bovine colostrum samples.” J Immunoassay. (1998 Feb 11). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/9530609
- Richard J. Bodnar. “Epidermal Growth Factor and Epidermal Growth Factor Receptor: The Yin and Yang in the Treatment of Cutaneous Wounds and Cancer.” Adv Wound Care (New Rochelle) (2013 Feb 20).
Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840479/
- Stanley Cohen. “Origins of Growth Factors: NGF and EGF.” J Biol Chem. (2008 Dec 5). Viewed at:
- Marius Raica and Anca Maria Cimpean. “Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy.” Pharmaceuticals (Basel) (2010 Mar 9).
Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033970/
- Johanna Andrae, Radiosa Gallini, and Christer Betsholtz. “Role of platelet-derived growth factors in physiology and medicine.” Genes Dev. (2008 May 15). Viewed at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732412/
- Papadea C, Check IJ. “Human immunoglobulin G and immunoglobulin G subclasses: biochemical, genetic, and clinical aspects.” Crit Rev Clin Lab Sci. (1989 Jan 8). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/2647414
- Legrand D. “Overview of Lactoferrin as a Natural Immune Modulator.” J Pediatr (2016 Jun 14). Viewed at:
- Donovan SM. “The Role of Lactoferrin in Gastrointestinal and Immune Development and Function: A Preclinical Perspective.” J Pediatr. (2016 Jun 22). Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/27234407
- P M Smallwood, I Munoz-Sanjuan, P Tong, J P Macke, S H Hendry, D J Gilbert, N G Copeland, N A Jenkins, and J Nathans. “Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.” Proc Natl Acad Sci U S A. (1996 Sep 3). Viewed at:
- Steger K, Tetens F, Seitz J, Grothe C, Bergmann M. “Localization of fibroblast growth factor 2 (FGF-2) protein and the receptors FGFR 1-4 in normal human seminiferous epithelium.” Histochem Cell Biol. (1998 Jul 2).
Viewed at: https://www.ncbi.nlm.nih.gov/pubmed/9681690
John has been a fitness enthusiast for over 10 years, starting out while struggling with obesity as a teenager. Over the years he has advised numerous clients on how to transform their physiques and their lives. As a writer on Nutrition Inspector he aims to help others achieve real results by staying clear of the common hype and false claims in the supplement industry!